Childhood Leukemia
The Trail to Information Literacy and Beyond
By Colin Dallimore
About the Project
For the 2015 fall semester at Emporia State University, I have been researching childhood leukemia in the class UL 100-A. This website contains a paper trail of the projects and research that I have completed on this topic. Because I am a nursing major, I chose to focus on health related topic. Due to personal interest, I choose Leukemia as my field of research and narrowed that down more to answer the question: 

How is Childhood Leukemia being treated with modern medicine, and what foundations are researching better, more effective ways of treating this disease?

This website contains detailed information on Childhood Leukemia purposed to answer this question. 
Topic Overview
Working Knowledge
          Leukemia is a cancerous disease that causes the body to produce an excess of white blood cells. This excess of cells is detrimental to a person because the white blood cells block red blood cells from accomplishing their respective jobs. There are many types of Leukemia that all fall under two broad categories. The first of which is myeloid Leukemia, this causes granulocytes to form issuing an inflammatory response. In this type of Leukemia, the lymph nodes, spleen, and liver grow causing discomfort and pain. The second type is lymphocytic Leukemia; this type is characterized by a white blood cell invasion that affects the central nervous system causing dizziness, headaches, and fevers.

          While both types of Leukemia affect different areas of the body, they are treated very similarly. This is largely due to the fact that white blood cells are produced in the bone marrow, so, to confirm a diagnosis of Leukemia, a bone marrow biopsy must be performed in order to affirm that there is an excess of white blood cells in the body. Once a diagnosis of Leukemia is confirmed, many treatment can be used to stop the overpopulation of white blood cells, such as: chemotherapy, radiation therapy, blood and plasma transfusions, and bone marrow transplants.

          However, many leukemia cases cannot be cured and the patient’s only option is to cope with the sad truth that the will soon pass. When the patient is told that they have only a short time to live, they might act out or suffer from depression. For these situations, numerous books have been written to help loved ones cope. One such book, Childhood Leukemia: A Guide for Families, Friends & Caregivers by Nancy Keene has been chosen for this project because it focuses on treating the patient when no medical treatments remain.

          Similarly to the way I chose the book source, I searched for sources related to treating and coping with leukemia. In turn, these sources revealed all the other relevant information to my topic. I exclusively used the Emporia State University Library’s Discovery Search to search for these sources. Some of the search terms I used were: leukemia, treatment, children, and coping. From the Discovery Search, I found five quality sources on this topic; one book source, one scholarly source, one magazine, and two online sources.



                                                         Works Cited

“Leukemia”. The Columbia Encyclopedia. Columbia University Press, 2015.
          http://search.credoreference.com/content/topic/leukemia?           searchId=83e0d534-5a88-11e5-98eb-0e18f8fa41cf. Web 09/13/15.

“Leukaemia”. Concise Medical Dictionary.
          http://www.oxfordreference.com/view/10.1093/oi/authority.20110803100102           237?rskey=Sdnd32&result=1. Web 09/13/15.
Concept Map
Research Outline
I. Intro: Leukemia
     A. Cancer Definition
     B. Leukemia Definition

II. Types
     A. Myeloid                                           
          1. affects         
          2. symptoms
     B. Lymphocytic                              
          1. affects                                   
          2. symptoms

III. Diagnosis
     A. Who gets Leukemia?
     B. How does one get Leukemia?
     C. Testing for Leukemia                
          1. excess of white blood cells
          2. bone marrow biopsy

IV. Treatment
     A. Chemotherapy
     B. Radiation therapy
     C. Plasma transfusions
     D. Bone marrow transplantation

V. How can you help?
     A. Leukemia Research Foundation
     B. Leukemia & Lymphoma Society
     C. Make-A-Wish Foundation
Infograhic
Annotated Bibliograpghy

                                                          Book Source

          This book is written for families, friends, and caregivers of people with leukemia who have no hope of a cure. It is intended that the book help those with loved ones who will soon pass away cope with the sad fact that they only have a short time left with each other. This source not only helps families, friends, and caregivers cope overall in their newly adjusted lives, it also helps get them through the day-to-day life of caring for someone with leukemia.
          Childhood Leukemia: A Guide for Families, Friends & Caregivers by Nancy Keene is up to date because it was published less than five years ago in 2010. This source relates to my research topic by answering the questions parents might have about dealing with the struggles of leukemia. The author, Nancy Keene, is a parent of a twenty year old cancer survivor. Keene now writes books to help others through what she went through. The purpose of this book is to provide parents of children with leukemia a guide to coping with this tough situation. Because she had a child who had leukemia, Keene’s information comes from numerous sources including A Child in Pain: How to Help, What to Do by Leora Kuttner and Acute Lymphocytic Leukemia. Acute Myelogenous Leukemia by the Leukemia Society of America, but because she has no certifications besides being a parent of a survivor, this source does not play into and scholarly research on leukemia. Because she is not certified as a doctor and presents no new research, this source is rated as a four.

                                                          Citation:

Keene,N. (2010). Childhood leukemia: A guide for families, friends & caregivers.
          Chicago: Childhood Cancer Guides.



                                                       Scholarly Source

          This article shows a very detailed study of treatments options for post transplant relapses of acute leukemia. An experiment was performed on 132 children who relapsed. It was found that second allogeneic transplant in children is an effective treatment for the relapse.
          “Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children: a single center experience” by Formankova R, Sedlacek P, Keslová P, Sramkova L, Zizkova H, & Stary J. is up to date because it was published less than five years ago in 2010. This source gives some cutting edge techniques for treating leukemia, give good weight to the treatment portion of my research topic. The authors are all scientists who are studying and researching leukemia actively. Because this article is peer reviewed, written by doctors affiliated with the Department of Pediatric Hematology and Oncology at Charles University, and cites eleven sources with authors just as qualified as themselves, it is an accurate source. It can also be verified through other sources. This source is available to let the scientific community know statistically how leukemia treatment is advancing. Because of the scholarly nature and weight of this source, it is rated with a five.

                                                           Citation:

Formankova R, Sedlacek P, Keslová P, Sramkova L, Zizkova H, & Stary J. (2010).           Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in           the treatment of post-transplant relapse of acute leukemia in children: a           single center experience. Leukemia & Lymphoma, 51(10), 1936-1940.



                                                Popular Magazine Article

          This magazine article tells readers in a few short paragraphs that the vaccine against HiB reduces the risk of cancer. Previously the reason it lowered risks was unknown to scientists, but thanks to recent discoveries, scientists have figured out how it lowers the risk of leukemia. It stops HiB infections from attacking children, and by doing so, stops them from affecting an enzyme that would turn precancerous blood cells into cancer.
          “How a Common Childhood Vaccine Helps Ward off Cancer” by Tessa Berenson is up to date because it was published less than five years ago in 2015. This source brings up a preventative technique for treating leukemia that fits well into the treatment portion of my research topic. The author is a reporter for Time magazine. Because she works for Time be and her facts are taken from a study published in Nature Immunology, it can be assumed that this source is reasonably accurate. The purpose of this article is to shed light on a potentially life changing vaccine that helps prevent cancer to the general public. This plays a significant role in the area of research because of the newness of this article, meaning that in the information cycle, this article is all we have on the subject so far. Because it is so new and only a magazine article, this source is rated as a three.

                                                            Citation:

Berenson,T. (2015, May 21). How a Common Childhood Vaccine Helps Ward Off           Cancer. Time.



                                                          Web Article

            This source gives a detailed account of how leukemia is treated. It starts by describing how it is diagnosed by a team of specialists. Then it goes on to discuss several options for treatments. Most notably it alerts readers to the fact that treating leukemia is a very intense battle that is hard to fight. Finally, it closes by warning patients to alert the doctor of any medications the patient might be taking as some drugs can have bad reactions to the leukemia treatments.
            “How is childhood leukemia treated?” is an article from the American Cancer Society’s website that is up to date because it was updated less than five years ago in 2015. It summarizes how treatment decisions are made by physicians. Because it comes from the American Cancer Society, this article is very accurate. The purpose of this article is to inform the general public of the treatments available for leukemia which in turn does not qualify this as significant to leukemia research. Based on these facts, this source is rated with a four.

                                                            Citation:

The American Cancer Society. (2015, April 17). How is childhood leukemia treated?.
          http://www.cancer.org/cancer/leukemiainchildren/detailedguide/childhood-           leukemia-treating-general-info. Retrieved November 10, 2015.



                                 Resources from Any Category: Web Article

          The information this source provides is in a very short article but has a few very important facts about leukemia. One important thing this source does is categorizes well the main types of childhood leukemia. Another fact this source presents is that leukemia accounts for 1 in 3 cancers in children.
          A web page from the American Cancer Society’s website is up to date with everything on the page being published within the last five years. This article is very detailed in explaining all facets of leukemia in children which makes it very useful for my research topic. Because it comes from the American Cancer Society, this page is very accurate. This article informs the general public about leukemia in general terms, and is very useful for people without a deep knowledge of medical terminology. Based on the broadness, accuracy, and ease of understanding of this source, it is rated with a five.

                                                              Citation:

The American Cancer Society. (2015, April 17). Leukemia in Children.           http://www.cancer.org/cancer/leukemiainchildren/index. Retrieved November           10, 2015.